Abstract Title:

Eutigoside C attenuates radiation-induced crypt injury in the mouse intestine.

Abstract Source:

Phytother Res. 2010 Jun;24(6):840-5. PMID: 19960418

Abstract Author(s):

Changjong Moon, Kyuyoung Ahn, Jihoon Kim, Jeongtae Kim, Sung-Ho Kim, Tae Heon Oh, Nam Ho Lee, Youngheun Jee, Jin Won Hyun, Jae Woo Park, Taekyun Shin

Article Affiliation:

Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju, South Korea.

Abstract:

On Jeju Island, South Korea, the leaves of Eurya emarginata have been traditionally used to treat ulcers or as a diuretic. Eutigoside C isolated from the leaves has been reported to have in vitro anti-inflammatory effects. We evaluated the radioprotective effects of eutigoside C on jejunal cell apoptosis and crypt survival in mice subjected to gamma irradiation. In addition, the ability of eutigoside C to protect against radiation-induced oxidative stress was examined by evaluating the activities of superoxide dismutase (SOD) and catalase (CAT) in radiation-induced hepatic injury. Eutigoside C was administered intraperitoneally at 48, 12, and 1 h before irradiation. The administration of eutigoside C (10, 50, or 100 mg/kg body weight) before irradiation protected the intestinal crypts from radiation-induced apoptosis (p<0.05), and attenuated radiation-induced decrease of villous height (p<0.05). Pretreating mice prior to irradiation with eutigoside C (100 mg/kg) significantly improved the survival of the jejunal crypt (p<0.01). The dose reduction factor was 1.09 at 3.5 days after irradiation. Treatment of eutigoside C prior to irradiation significantly protected SOD and CAT activities in radiation-induced hepatic injury (p<0.05). These results suggest that eutigoside C is a useful radioprotector capable of defending intestinal progenitor cells against indirect depletion, such as oxidative stress and inflammatory response caused by gamma irradiation.

Study Type : Animal Study

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