Abstract Title:

Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.

Abstract Source:

Nepal Med Coll J. 2006 Sep ;8(3):156-61. PMID: 17203820

Abstract Author(s):

Manoranjan Adak, Joyanta Kumar Gupta

Article Affiliation:

Manoranjan Adak


To evaluate the effect of Calotropis G in various experimental animal models. The anti-inflammatory activity was evaluated using carrageenin-induced kaolin -induced rat paw oedema for acute and cotton-pellet granuloma, adjuvant-induced arthritis model for chronic inflammation. Antipyretic activity was carried out using yeast induced pyresis method. Phenylquinone--induced writhing method in mice was used for analgesic activity. Test compounds exhibited variable anti-inflammatory activity and peak activity of the test compounds were reached at 2 h. Alkaloid fraction possesses comparatively high initial anti-inflammatory activity. The residual anti-inflammatory activity of alkaloid fraction of Calotropis G suggest either a greater protein binding nature of the compound there by providing a slow released pool of active drug molecule in the system or non available of possible bioactive metabolites to retain the activity profile relation.

Study Type : Animal Study

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