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Abstract Title:

Evaluation ofα-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:754931. Epub 2015 Nov 16. PMID: 26649063

Abstract Author(s):

Elsnoussi Ali Mohamed, Mariam Ahmad, Lee Fung Ang, Mohd Zaini Asmawi, Mun Fei Yam

Article Affiliation:

Elsnoussi Ali Mohamed

Abstract:

In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for itsα-glucosidase inhibitory activity. In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3'hydroxy-5,6,7,4'-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α-glucosidase in normal rats loaded with starch and sucrose. Theresults showed that 1000 mg/kg of the 50% ethanolic extract of O. stamineus significantly (P<0.05) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose. In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly (P<0.05) lower plasma glucose levels after starch loading. Hence,α-glucosidase inhibition might be one of the mechanisms by which O. stamineus extract exerts its antidiabetic effect. Furthermore, our findings indicated that the 50% ethanolic extract of O. stamineus can be considered as a potential agent for the management of diabetes mellitus.

Study Type : Animal Study

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