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Article Publish Status: FREE
Abstract Title:

Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms.

Abstract Source:

Oxid Med Cell Longev. 2017 ;2017:4314025. Epub 2017 May 29. PMID: 28630658

Abstract Author(s):

Keren K Griffiths, Richard J Levy

Article Affiliation:

Keren K Griffiths

Abstract:

Autism spectrum disorder (ASD), the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as restricted and repetitive behavior. The underlying cause of autism is unknown and therapy is currently limited to targeting behavioral abnormalities. Emerging studies suggest a link between mitochondrial dysfunction and ASD. Here, we review the evidence demonstrating this potential connection. We focus specifically on biochemical links, genetic-based associations, non-energy related mechanisms, and novel therapeutic strategies.

Study Type : Review

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