Abstract Title:

Exercise Prevents Diet-induced Cellular Senescence in Adipose Tissue.

Abstract Source:

Diabetes. 2016 Mar 16. Epub 2016 Mar 16. PMID: 26983960

Abstract Author(s):

Marissa J Schafer, Thomas A White, Glenda Evans, Jason M Tonne, Grace C Verzosa, Michael B Stout, Daniel L Mazula, Allyson K Palmer, Darren J Baker, Michael D Jensen, Michael S Torbenson, Jordan D Miller, Yasuhiro Ikeda, Tamara Tchkonia, Jan M van Deursen, James L Kirkland, Nathan K LeBrasseur

Article Affiliation:

Marissa J Schafer


Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise prevents premature senescent cell accumulation and systemic metabolic dysfunction induced by a fast food diet (FFD). Using transgenic mice that express enhanced green fluorescent protein (EGFP) in response to activation of the senescence-associated p16(INK4a) promoter, we demonstrate that FFD consumption causes deleterious changes in body weight and composition, as well as measures of physical, cardiac, and metabolic health. The harmful effects of the FFD were associated with dramatic increases in several markers of senescence, including p16, EGFP, senescence-associatedβ-galactosidase, and the senescence-associated secretory phenotype (SASP), specifically in visceral adipose tissue. We show that exercise prevents both the accumulation of senescent cells and the expression of the SASP, while nullifying the damaging effects of the FFD on parameters of health. We also demonstrate that exercise initiated following long-term FFD-feeding reduces senescent phenotype makers in visceral adipose while attenuating physical impairments, suggesting that exercise may provide restorative benefit by mitigating accrued senescent burden. These findings highlight a novel mechanism by which exercise mediates its beneficial effects and reinforce the impact of modifiable lifestyle choices on healthspan.

Study Type : Transgenic Animal Study
Additional Links
Therapeutic Actions : Exercise : CK(4855) : AC(736)
Anti Therapeutic Actions : Western Diet : CK(416) : AC(121)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.