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Abstract Title:

The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE).

Abstract Source:

Neuropeptides. 2011 Jun ;45(3):189-95. Epub 2011 Feb 21. PMID: 21334743

Abstract Author(s):

Jolanta Wasilewska, Edyta Sienkiewicz-Szłapka, Ewa Kuźbida, Beata Jarmołowska, Maciej Kaczmarski, Elżbieta Kostyra

Article Affiliation:

Department of Paediatrics, Gastroenterology and Allergic Diseases, The Medical University of Białystok, Poland.

Abstract:

Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovineβ-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.

Study Type : Human Study
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Sayer Ji
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