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Abstract Title:

Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice.

Abstract Source:

Int J Biol Macromol. 2021 Feb 15 ;170:652-663. Epub 2021 Jan 5. PMID: 33359803

Abstract Author(s):

Huaping Li, Yanbo Feng, Wenxue Sun, Yi Kong, Le Jia

Article Affiliation:

Huaping Li

Abstract:

The mycelia polysaccharides (MPS) from Pleurotus djamor were prepared and purified by anion exchange column chromatography, and the phosphate content of phosphorylated MPS (PMPS) was 15.22± 0.37%. FT-IR spectra, HPLC andH andC-NMR results showed the PMPS containedα-pyranose structure and the peak area percentage composition of galacturonic acid and glucose were 13.01% and 85.82%, respectively. Animal experiment investigated the antioxidant, anti-inflammation, anti-fibrosis effects of PMPS on kidney in adenine-induced chronic renal failure (CRF) mice. All results including serum biochemical indices, histopathological observation, qRT-PCR, western blotting, immunohistochemical staining manifested the kidney injury could be remitted by PMPS interventions. This experiment suggested that PMPS could remit CRF and other kidney injury related diseases as onekind of dietary supplements and functional foods without toxic side effects.

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