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Article Publish Status: FREE
Abstract Title:

Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.

Abstract Source:

Part Fibre Toxicol. 2014 Oct 30 ;11:57. Epub 2014 Oct 30. PMID: 25358535

Abstract Author(s):

Greg I Lee, Jordy Saravia, Dahui You, Bishwas Shrestha, Sridhar Jaligama, Valerie Y Hebert, Tammy R Dugas, Stephania A Cormier

Article Affiliation:

Greg I Lee

Abstract:

BACKGROUND: Exposures to elevated levels of particulate matter (PM) enhance severity of influenza virus infection in infants. The biological mechanism responsible for this phenomenon is unknown. The recent identification of environmentally persistent free radicals (EPFRs) associated with PM from a variety of combustion sources suggests its role in the enhancement of influenza disease severity.

METHODS: Neonatal mice (

RESULTS: Neonates exposed to EPFRs had significantly enhanced morbidity and decreased survival following influenza infection. Increased oxidative stress was also observed in EPFR exposed neonates. This correlated with increased pulmonary Tregs and dampened protective T cell responses to influenza infection. Reduction of EPFR-induced oxidative stress attenuated these effects.

CONCLUSIONS: Neonatal exposure to EPFR containing PM resulted in pulmonary oxidative stress and enhanced influenza disease severity. EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.

Study Type : Human Study

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