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Abstract Title:

Exposure to GSM 900-MHz mobile radiation impaired inhibitory avoidance memory consolidation in rat: involvements of opioidergic and nitrergic systems.

Abstract Source:

Brain Res. 2018 Jul 18. Epub 2018 Jul 18. PMID: 30030983

Abstract Author(s):

Shamseddin Ahmadi, Samaneh Sadat Alavi, Majid Jadidi, Abolfazl Ardjmand

Article Affiliation:

Shamseddin Ahmadi

Abstract:

The use of mobile phones is increasing, and the main health concern is the possible deleterious effects of radiation on brain functioning. The present study aimed to examine the effects of exposure to a global system for mobile communication (GSM) with mobile phones on inhibitory avoidance (IA) memory performance as well as the involvement of endogenous opioids and nitric oxide (NO) in this task. Male Wistar rats, 10-12weeksold, were used. The results showed that four weeks of mobile phone exposure impaired IA memory performance in rats. The results also revealed that post-training, but not pre-training, as well as pre-test intracerebroventricular (i.c.v.) injections of naloxone (0.4, 4 and 40 ng/rat), dose-dependently recovered the impairment of IA memory performance induced by GSM radiation. Additionally, the impairment of IA memory performance was completely recovered in the exposed animals with post-training treatment of naloxone (40 ng/rat) plus pre-test i.c.v. injections of L-arginine (100 and 200 nmol/rat). However, pre-test i.c.v. injections of L-NAME(10 and 20 nmol/rat), impaired IA memory performance in the animals receiving post-training naloxone (40 ng/rat). In the animals receiving post-training naloxone treatment, the impairment of IA memory performance due to pre-test i.c.v. injections of L-NAME was recovered by the pre-test co-administration of L-arginine. It was concluded that the recovery from impairment of IA memory in GSM-exposed animals with post-training naloxone treatment was the result of blockade of the opioidergic system in early memory consolidation as well as activation of the nitrergic system in the retrieval phase of memory.

Study Type : Animal Study
Additional Links
Anti Therapeutic Actions : Mobile Phone Radiation : CK(64) : AC(13)
Adverse Pharmacological Actions : Neurotoxic : CK(1458) : AC(323)

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