Association of Ambient air Pollution with risk of preeclampsia during pregnancy: a retrospective cohort study.
BMC Public Health. 2020 Nov 5 ;20(1):1663. Epub 2020 Nov 5. PMID: 33153479
BACKGROUND: Ambient air pollution is becoming a serious environmental problem in China. The results were inconsistent on that air pollution was a risk factor of preeclampsia in pregnancy.
METHODS: Total 116,042 pregnant women were enrolled from 22 hospitals in 10 cities of Hebei Province, China from January 1, 2015 to December 31, 2017. The parturients were divided into preeclampsia group (PE group) and non-preeclampsia group (non-PE group). The data of air pollutants, namely, particulate matter (PM)2.5, PM, NO, SO, CO, Owere collected from China Environmental Inspection Station.
RESULTS: Among the 116,042 pregnant women, 2988 (2.57%) pregnant women were diagnosed with preeclampsia. The concentrations of exposed PM, PM, NOand Oin the PE group were significantly higher than those in the non-PE group, and they were risk factors of the PE group in the first and second trimester of pregnancy respectively. The concentrations of exposed SOand CO in PE patients and non-PE women were not different, but high concentration of these air pollutants were risk factors to PE in the second trimester.
CONCLUSION: The exposure to PM, PM, NO, Owere risk factors for preeclampsia in the first and second trimester of pregnancy, while only at high level, SOand CO were risk factors for preeclampsia in the second trimester of pregnancy.