Article Publish Status: FREE
Abstract Title:

An Extract ofL. Promotes Psychological Resilience in a Mouse Model of Depression.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:7418681. Epub 2018 May 13. PMID: 29861834

Abstract Author(s):

Jun Wang, Adelaida Esteban Fernández, Simoni Tiano, Jing Huang, Elizabeth Floyd, Alexander Poulev, David Ribnicky, Giulio M Pasinetti

Article Affiliation:

Jun Wang


Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models. PMI 5011, a botanical extract ofL., was previously shown to have multiple bioactivities, including anti-inflammatory activity. In this work, using a repeated social defeat stress (RSDS) model of depression, we demonstrate that oral administration of the botanical extract PMI 5011 promotes resilience to RSDS-mediated depression-like phenotypes. We also show that the behavioral improvements are associated with attenuation of stress-mediated induction of inflammatory cytokines in the periphery and alteration of synaptic plasticity in the nucleus accumbens (NAc). Our studies provide experimental evidence that botanical extracts such as PMI 5011, which target pathological mechanisms (i.e., peripheral inflammation) not addressed by currently available antidepressants, could be further developed as novel therapeutics for the treatment of stress disorders and anxiety in humans.

Study Type : Animal Study

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