Abstract Title:

Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis.

Abstract Source:

Phytochemistry. 2015 Aug ;116:203-12. Epub 2015 May 28. PMID: 26028520

Abstract Author(s):

Toshio Morikawa, Kiyofumi Ninomiya, Yasunobu Takamori, Eriko Nishida, Misato Yasue, Takao Hayakawa, Osamu Muraoka, Xuezheng Li, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda

Article Affiliation:

Toshio Morikawa


The methanol extract from Bellis perennis (Asteraceae) flowers was found to promote collagen synthesis in normal human dermal fibroblasts (NHDFs). Seven oleanane-type triterpene saponins, perennisosides XIII-XIX, and two known saponins, bellissaponins BS5 and BS9, were isolated from the methanol extract. The structures were determined based on chemical and physicochemical data, and confirmed using previously isolated related compounds as references. Among the isolates, including 19 previously reported saponins, perennisosides XVIII, I, II, VII, IX, and XI, asterbatanoside D, bernardioside B2, and bellissaponins BS5 and BS9 significantly promoted collagen synthesis at 3-30μM without cytotoxicity.

Study Type : Animal Study
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