Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Article Publish Status: FREE
Abstract Title:

Hypolipidemic Effect ofLeaf Extract Against Hepatotoxicity in Rats.

Abstract Source:

Pharmacogn Mag. 2018 Jan-Mar;14(53):4-8. Epub 2018 Feb 20. PMID: 29576694

Abstract Author(s):

K Vijayakumar, R L Rengarajan, R Radhakrishnan, A Vijaya Anand

Article Affiliation:

K Vijayakumar

Abstract:

Background: Plant-based natural extracts cure several diseases in human. However, the extract ofleaf is not yet evaluated on changes of lipid profile in hepatic disease affected rats.

Objective: The present study was aimed to evaluate the mitigation effect of the ethanolic extract ofleaf and its isolated quercetin fraction on hepatotoxic rats.

Materials and Methods: Carbon tetrachloride (CCl) was injected to rats for hepatic disease induction and silymarin drug was used as positive control to compare plant ethanolic extract. The lipid profiles were assessed in both plasma and liver tissue of diseased and control rats.

Results: Levels of total cholesterol, triglycerides, free fatty acids, phospholipids, and low-density lipoprotein cholesterol were increased and the level of high-density lipoprotein cholesterol (HDL-C) was decreased in CCl-induced hepatotoxic rats. The treatment of(100, 200, and 300 mg/kg, bw) and isolated quercetin fraction (20 mg/kg, bw) doses decreased the elevated levels of all these parameters in diseased rats and restored the normal concentration of HDL-C.

Conclusion: The results of the present study concluded that theleaf and its isolated quercetin fraction can significantly regulate lipid metabolism in CCl-induced hepatotoxic rats and decrease the disease rate.

SUMMARY: leaf extract reduces the hepatotoxicity and disease rate in ratsQuercetin fraction of leaf extract significantly regulates lipid profile in hepatic diseased rats.CCl: Carbon tetrachloride; FFA: Free fatty acids; HDL-C: High-density lipoprotein cholesterol; LCAT: Lecithin cholesterol acyltransferase; LDL-C: Low-density lipoprotein cholesterol; PL: Phospholipids; TC: Total cholesterol; TG: Triglycerides; VLDL-C: Very low-density lipoprotein cholesterol.

Study Type : Animal Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.