and its main ingredient, carvacrol, affect on the renal function, histopathological, biochemical and antioxidant parameters in adriamycin-induced nephrotic rats.
Arch Physiol Biochem. 2019 Aug 9:1-9. Epub 2019 Aug 9. PMID: 31397187
Oxidative stress has a major role in the nephrosis. In the present study, the effects of hydroalcoholic extract of(ZM) and carvacrol (CAR) were evaluated on the renal damage induced by adriamycin (ADR). The animals accidentally divided into four groups including: Control, ADR, ZM + ADR and CAR + ADR. The renal tissue, urine, and blood samples subjected to biochemical markers and histopathological evaluation. ADR significantly decreased glomerular filtration rate (GFR) while escalated urine protein excretion as well as protein clearance ( < .01 to < .001). Also, ADR significantly reduced the antioxidants and boosted the malondialdehyde (MDA) compared to the control ( < .05 to < .01). In groups treated by ZM and CAR, GFR, and antioxidants significantly increased, whereas urine protein excretion and MDA decreased ( < .05 to < .001). ZM and CAR induced an improvement in ADR-induced renal damage by improving renal function as well as antioxidant activity.