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Abstract Title:

Morphological Changes Induced By Extremely Low-Frequency Electric Fields.

Abstract Source:

Bioelectromagnetics. 2019 Sep ;40(6):375-390. Epub 2019 Jun 3. PMID: 31157927

Abstract Author(s):

Mahdi Imani, Sepide Kazemi, Mehrdad Saviz, Leila Farahmand, Behnam Sadeghi, Reza Faraji-Dana

Article Affiliation:

Mahdi Imani

Abstract:

In this paper, morphological effects of electric fields on avian erythrocytes (nucleated red blood cells) have been studied in detail. Morphological changes include rounding and cytoplasm transparency. It has been shown that the effect is non-thermal. Careful imaging and image analyses have been carried out to show that the degree of this effect is frequency-dependent, and has a higher conversion rate at higher temperatures. Furthermore, to better understand the mechanisms behind the morphological changes, we investigated the dedifferentiation hypothesis and performed a series of tests on avian erythrocytes including fluorescence spectroscopy for hemoglobin, and tests on human umbilical cord blood, mesenchymal stem cells, and bone marrow mesenchymal stem cells including flow-cytometry analysis for expression of certain markers and calcium staining. Bioelectromagnetics. 2019;40:375-390.© 2019 Bioelectromagnetics Society.

Study Type : In Vitro Study
Additional Links
Adverse Pharmacological Actions : Cytotoxic : CK(89) : AC(53)

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