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Abstract Title:

Oxidative stress and apoptosis in relation to exposure to magnetic field.

Abstract Source:

Cell Biochem Biophys. 2011 Mar ;59(2):71-7. PMID: 20824388

Abstract Author(s):

Mustafa Emre, Salih Cetiner, Sevil Zencir, Isa Unlukurt, Ibrahim Kahraman, Zeki Topcu

Article Affiliation:

Mustafa Emre

Abstract:

We investigated the effect of extremely low-frequency electromagnetic field (ELF-EMF) with pulse trains exposure on lipid peroxidation, and, hence, oxidative stress in the rat liver tissue. The parameters that we measured were the levels of plasma alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase as well as plasma albumin, bilirubin, and total protein levels in 30 adult male Wistar rats exposed to ELF. We also determined the percentage of apoptotic and necrotic cells of the kidney extracts from the animals by flow cytometry method. Apoptotic cell death was further characterized by monitoring DNA degradation using gel electrophoresis. The results showed an increase in the levels of oxidative stress indicators, and the flow cytometric data suggested a possible relationship between the exposure to magnetic field and the cell death. We showed significantly lower necrotic cell percentages in experimental animals compared to either unexposed or sham control groups. However, DNA ladder analyses did not differentiate between the groups. Our results were discussed in relation to the response of biological systems to EMF.

Study Type : In Vitro Study

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