Article Publish Status: FREE
Abstract Title:

Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus.

Abstract Source:

PLoS One. 2013 ;8(2):e55380. Epub 2013 Feb 6. PMID: 23405142

Abstract Author(s):

Muya Shu, Yanhan Wang, Jinghua Yu, Sherwin Kuo, Alvin Coda, Yong Jiang, Richard L Gallo, Chun-Ming Huang

Article Affiliation:

Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Abstract:

Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health.

Study Type : Bacterial

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Sayer Ji
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