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Article Publish Status: FREE
Abstract Title:

Effects of fermented black ginseng on wound healing mediated by angiogenesis through the mitogen-activated protein kinase pathway in human umbilical vein endothelial cells.

Abstract Source:

J Ginseng Res. 2018 Oct ;42(4):524-531. Epub 2017 Jul 25. PMID: 30337813

Abstract Author(s):

Jun Yeon Park, Dong-Soo Lee, Chang-Eop Kim, Myoung-Sook Shin, Chang-Seob Seo, Hyeun-Kyoo Shin, Gwi Seo Hwang, Jun Min An, Su-Nam Kim, Ki Sung Kang

Article Affiliation:

Jun Yeon Park

Abstract:

Background: Fermented black ginseng (FBG) is produced through several cycles of steam treatment of raw ginseng, at which point its color turns black. During this process, the original ginsenoside components of raw ginseng (e.g., Re, Rg1, Rb1, Rc, and Rb2) are altered, and less-polar ginsenosides are generated (e.g., Rg3, Rg5, Rk1, and Rh4). The aim of this study was to determine the effect of FBG on wound healing.

Methods: The effects of FBG on tube formation and on scratch wound healing were measured using human umbilical vein endothelial cells (HUVECs) and HaCaT cells, respectively. Protein phosphorylation of mitogen-activated protein kinase was evaluated via Western blotting. Finally, the wound-healing effects of FBG were assessed using an experimental cutaneous wounds model in mice.

Results and Conclusion: The results showed that FBG enhanced the tube formation in HUVECs and migration in HaCaT cells. Western blot analysis revealed that FBG stimulated the phosphorylation of p38 and extracellular signal-regulated kinase in HaCaT cells. Moreover, mice treated with 25 μg/mL of FBG exhibited faster wound closure than the control mice did in the experimental cutaneous wounds model in mice.

Study Type : Animal Study

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