Evaluation of the hepatoprotective effect of combination between fermented camel milk andleaves extract against CClinduced liver toxicity in mice.
J Food Sci Technol. 2019 Feb ;56(2):824-834. Epub 2019 Jan 5. PMID: 30906040
The present study was conducted to evaluate the in vitro antioxidant activity of fermented camel milk withsubsp.(FCM-LLC) alone,extract (R) alone and their combination and to investigate their hepatopreventive effects against CClliver damage in mice. The antioxidant activity in vitro of FMC-LLC supplemented with R exhibited the highest free radical scavenging and ferric reducing power activities. The results showed that the pretreatment with a combination of FMC-LLC and R significantly alleviated the increased levels of hepatic markers and the elevated lipid levels induced by CClin mice. Meanwhile, the enzymatic antioxidants activities (superoxide dismutase, glutathione peroxidase, and catalase) and GSH level in liver significantly were increased while the malondialdehyde level was significantly improved by pretreatment with FMLLC plus R. These data suggest that FCM-LLC in combination withextract possesses better antioxidant and hepatoprotective activity than FMC-LLC alone.