Anti-obese Effects of a Mixture of Fermented Ginseng,BORI, andCH88 in high-fat diet-fed mice.
J Microbiol Biotechnol. 2018 Mar 16. Epub 2018 Mar 16. PMID: 29551020
Ginseng and probiotics have anti-obese effects in mice fed a high-fat diet(HFD). Absorption of ginsenoside and colonization of probiotics occur in the intestine. In this study, the mixture of fermented ginseng and two probiotics,BORI andCH88, was administered to HFD fed mice for 9 weeks. The mixture significantly suppressed weight gain (<0.05,= 8) and lipid deposition in the liver and adipose tissues as well as increased the mice's food intake. The adipocyte size of the adipose tissue was significantly decreased in the mixture group, especially when 0.5% fermented ginseng and 5×10/mL two probiotics were used (<0.05,= 10). The expression of TNF-α in adipose tissue was efficiently down-regulated in the mixture group (<0.05,= 4). The supplement also improved the mice's fasting blood glucose levels(<0.05,= 8) and total cholesterol feces excretion (<0.05,= 8). The mixture of fermented ginseng andBORI andCH88 could have an anti-obese effects and suppress lipid deposit in the liver and adipose tissues.