Abstract Title:

Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice.

Abstract Source:

Int J Radiat Biol. 2011 Jan 24. Epub 2011 Jan 24. PMID: 21254928

Abstract Author(s):

Zeng-Chun Ma, Qian Hong, Yu-Guang Wang, Hong-Ling Tan, Cheng-Rong Xiao, Qian-De Liang, Bei-Bei Lu, Yue Gao

Article Affiliation:

Beijing Institute of Radiation Medicine, Beijing, P. R. China.

Abstract:

Purpose: The objective of this study was to investigate the mechanism for ferulic acid (FA)-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology. Materials and methods: Balb/c mice were irradiated at a dose of 2.5 Gy using cobalt-60 gamma resources. Following irradiation, FA was administered intragastrically for seven consecutive days. Hematopoietic progenitor colony-forming cell assays were used to assess the reconstitution of bone marrow after radiation-induced myelosuppression. Cytokine levels were investigated using enzyme-linked immunosorbentassay and Western blot analysis. Results: The results demonstrated that FA treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. FA administration increased levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin. Conclusion: These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.

Study Type : Animal Study

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