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Article Publish Status: FREE
Abstract Title:

Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study.

Abstract Source:

Environ Res. 2020 Jul ;186:109602. Epub 2020 May 1. PMID: 32668547

Abstract Author(s):

Charissa van Zwol-Janssens, Leonardo Trasande, Alexandros G Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Elise M Philips, Fernando Rivadeneira, Vincent W V Jaddoe, Susana Santos

Article Affiliation:

Charissa van Zwol-Janssens

Abstract:

BACKGROUND: Exposure to bisphenols and phthalates might influence bone health. We hypothesized that exposure to bisphenols and phthalates during fetal life has persistent effects on bone development.

OBJECTIVES: To analyze the associations of fetal exposure to bisphenols and phthalates with bone health in school-aged children.

METHODS: Among 1,362 mother-child pairs participating in a population-based cohort study, we measured maternal urinary concentrations of bisphenols and phthalates at first, second and third trimester with high performance liquid chromatography electrospray ionization-tandem mass spectrometry. Total body bone mineral density (BMD) and bone area (BA) were measured using dual-energy X-ray absorptiometry (DXA) at 6 and 10 years, and were both used to calculate bone mineral content (BMC) and area-adjusted BMC (aBMC, a measure of volumetric BMD).

RESULTS: Maternal bisphenol concentrations were not associated with childhood bone measures at 6 years. After adjustment for covariates and multiple testing correction, an interquartile range increase in maternal first trimester bisphenol S (BPS) concentrations was associated with lower BMD and aBMC at 10 years (-6.08 (95% confidence interval (CI), -9.97 to -2.19) mg/cmand -0.12 (95% CI, -0.20 to -0.04) g). Maternal third trimester low molecular weight (LMW) phthalate concentrations were associated with higher aBMC at 6 years whereas, maternal third trimester di-n-octylphthalate (DNOP) concentrations were associated with lower aBMC at 10 years. However, these associations did not remain statistically significant after multiple testing correction.

DISCUSSION: Maternal first trimester BPS concentrations are associated with lower BMD and aBMC in school-aged children. These findings should be considered as hypothesis generating and need further replication and exploration of potential underlying mechanisms.

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