Article Publish Status: FREE
Abstract Title:

Antibacterial activity of fig leaf (Linn.) extract againstand its cytotoxicity effects on fibroblast cells.

Abstract Source:

Vet World. 2018 Mar ;11(3):342-347. Epub 2018 Mar 20. PMID: 29657427

Abstract Author(s):

Intan Nirwana, Devi Rianti, R Helal Soekartono, Rr Dwi Listyorini, Desi Putri Basuki

Article Affiliation:

Intan Nirwana


Background: is one of the bacteria that commonly found in root canal and pulp infection after root canal treatment. Sodium hypochlorite is the most widely used root canal irrigation, but it has toxic properties if exposed to periradicular tissues. It is necessary to develop an alternative for root canal irrigation. Fig leaf (Linn.) extract contains active substances such as flavonoid, tannin, and terpenoid which have been known for their antibacterial potency.

Aim: This study aimed to determine the minimum bactericidal concentration (MBC) of fig leaf (Linn.) extract againstand its cytotoxicity on fibroblast cells.

Materials and Methods: A serial dilution method was used to determine the MBC of fig leaf extract onwhich grown on nutrient agar media. Inoculation was carried out at concentrations that suspected minimum inhibitory concentration (MIC), MBC, concentration between MIC and MBC, and control groups on different nutrient agar. MIC and MBC of fig leaf extract againstwere known by counting the growth of bacteria colonies on nutrient agar media in CFU/ml. The cytotoxicity of MIC and MBC of the extract acquired were tested using 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the results were read using an ELISA reader. Data ofcolonies were analyzed using Kruskal-Wallis and Mann-Whitney test.

Results: The result showed a significant difference among the groups (p<0.05). fig leaf extract at a concentration of 50% showed no bacterial growth, and cell viability at this concentration was 77.7%.

Conclusion: Fig leaf extract has antibacterial effect onwith MBC at 50% and not cytotoxic to fibroblast cells.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.