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Abstract Title:

Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of ischemic stroke: a case-control study.

Abstract Source:

Am J Clin Nutr. 2019 02 1 ;109(2):1-7. PMID: 30753322

Abstract Author(s):

Taoping Sun, Yanwei Zhang, Hao Huang, Xiaoqian Wang, Li Zhou, Shuzhen Li, Suli Huang, Changhui Xie, Ying Wen, Yalun Zhu, Xiaoli Hu, Liangkai Chen, Peiyun Li, Sijing Chen, Wei Yang, Wei Bao, Frank B Hu, Jinquan Cheng, Liegang Liu

Article Affiliation:

Taoping Sun

Abstract:

Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association.

Objectives: The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke.

Methods: A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke riskthrough the use of logistic regression.

Results: Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes.

Conclusions: Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.

Study Type : Human Study

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Sayer Ji
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