Article Publish Status: FREE
Abstract Title:

Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial.

Abstract Source:

BMC Nephrol. 2018 Dec 27 ;19(1):379. Epub 2018 Dec 27. PMID: 30591031

Abstract Author(s):

Afshin Samaei, Monir Nobahar, Zaynab Hydarinia-Naieni, Abbas Ali Ebrahimian, Mohammad Reza Tammadon, Raheb Ghorbani, Abbas Ali Vafaei

Article Affiliation:

Afshin Samaei


BACKGROUND: The prevalence of cognitive disorders in hemodialysis patients is twice as high as the general population, while these disorders often are undiagnosed. Timely prevention and treatment can improve their personal and social functions. Aim of study was determined the effect of Valerian on cognitive disorders and electroencephalography (EGG) in hemodialysis patients.

METHODS: This crossover, double-blind clinical trial was conducted on 39 hemodialysis patients. The patients were randomly divided into two groups. Group A (n = 19) took Valerian capsules and Group B (n = 20) received placebo capsules 60 min before bedtime for one month. The type of treatment was replaced between the two groups after a one-month wash-out. The Mini Mental State Examination (MMSE) questionnaire was completed and EGG was performedbefore and after intervention in both periods.

RESULTS: The cognitive scores of the Group valerian were increased significantly in the first (p = 0.003) and the second (p = 0.005) periods. In addition, the mean increase in the cognitive scores in the Group valerian was significant in the first (p = 0.028) and the second periods (p = 0.030). However, the changes in EGG showed no significant difference before and after intervention in two groups.

CONCLUSION: The findings of this study indicated that valerian could be effective and significantly improve patients' cognitive status; however, no significant changes were observed in the electroencephalography of the hemodialysis patients.

TRIAL REGISTRATION: IRCT201606076318N7 -2016-06-17.

Study Type : Human Study

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