Article Publish Status: FREE
Abstract Title:

Metabolomic Screening of Anti-Inflammatory Compounds from the Leaves of(Hardy Kiwi).

Abstract Source:

Foods. 2019 Feb 1 ;8(2). Epub 2019 Feb 1. PMID: 30717099

Abstract Author(s):

Gyoung-Deuck Kim, Jin Young Lee, Joong-Hyuck Auh

Article Affiliation:

Gyoung-Deuck Kim


The metabolomic screening of potential anti-inflammatory compounds in the leaves ofwas performed by using LC-MS/MS. Ethanol extracts were prepared, and the anti-inflammatory effects were investigated based on nitric oxide (NO) synthesis and inducible nitric oxide synthase expression in lipopolysaccharide-induced RAW 264.7 macrophages. The 75% ethanol extract showed the highest inhibitory effect on nitric oxide (NO) production, and it was further separated by in vitro bioassay-guided fractionation using preparative LC with reversed-phase column separation. Through multiple steps of fractionation, sub-fraction 1-3 was finally purified, and caffeic acid derivatives, such as caffeoylthreonic acid and danshensu (salvianic acid A), were successfully identified as key anti-inflammatory compounds by LC-MS/MS and metabolomics analyses. This is the first study identifying anti-inflammatory compounds in() leaves through bioassay-guided fractionation and metabolomics screening. Results of this study would be useful for the application ofleaves as a nutraceutical.

Study Type : In Vitro Study

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