Abstract Title:

The Potential of Flavonoids in the Treatment of Non-alcoholic Fatty Liver Disease.

Abstract Source:

Crit Rev Food Sci Nutr. 2015 Apr 21:0. Epub 2015 Apr 21. PMID: 25897647

Abstract Author(s):

Bregje Van De Wier, Ger H Koek, Aalt Bast, Guido R M M Haenen

Article Affiliation:

Bregje Van De Wier

Abstract:

The contemporary pathophysiological model of non-alcoholic fatty liver disease (NAFLD) consists of multiple parallel pathways with a dynamic cross talk that cumulate in steatosis and inflammation and ultimately fibrosis, cirrhosis, liver failure and hepatocellular carcinoma. So far, no pharmacological treatment has been approved. A major impediment of drugs in general is that they are intended to act on one single target in the pathology of a disease. However, the multitude of pathways involved in the pathogenesis of NAFLD underpins the need for treatments that address these various pathways. Interestingly, flavonoids have been found to have positive effects on lipid metabolism, insulin resistance, inflammation and oxidative stress, the most important pathophysiological pathways in NAFLD. This puts flavonoids in the spotlight for the treatment of NAFLD and prompted us to review the existing evidence for the use of these food derived compounds in the treatment of NAFLD.

Study Type : Review

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.