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Abstract Title:

Effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.

Abstract Source:

Clin Nutr ESPEN. 2020 Dec ;40:27-33. Epub 2020 Oct 16. PMID: 33183549

Abstract Author(s):

Omid Reza Tamtaji, Alireza Milajerdi, Željko Reiner, Ehsan Dadgostar, Elaheh Amirani, Zatollah Asemi, Liaosadat Mirsafaei, Mohammad Ali Mansournia, Parisa Maleki Dana, Fatemeh Sadoughi, Jamal Hallajzadeh

Article Affiliation:

Omid Reza Tamtaji

Abstract:

OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome (MetS) and related disorders.

METHODS: Databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central library were searched until January 31, 2019.

RESULTS: 14 effect sizes from 12 studies were identified eligible to be included in current meta-analysis. Flaxseed supplementation resulted in a significant reduction in interleukin 6 (IL-6) (WMD: -0.22; 95% CI: -0.43, -0.01) and malondialdehyde (MDA) (WMD: -0.17; 95% CI: -0.31, -0.03) and a significant increase in total antioxidant capacity (TAC) levels (WMD: 137.25; 95% CI: 68.04, 206.47). Flaxseed oil supplementation did not affect other biomarkers of inflammation and oxidative stress.

CONCLUSIONS: Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. This suggests that flaxseed oil supplementation may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.

Study Type : Meta Analysis, Review

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