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Abstract Title:

Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on HO-damaged pancreatic cells.

Abstract Source:

J Nat Med. 2019 Jun 29. Epub 2019 Jun 29. PMID: 31256310

Abstract Author(s):

Jiayin Yue, Yuanyuan Sun, Jing Xu, Xiaoshu Zhang, Yuqing Zhao

Article Affiliation:

Jiayin Yue

Abstract:

Four new cucurbitane-type triterpenes were isolated from the fruit of Momordica charantia L. The structures of the new compounds were identified based on HR-ESI-MS and 1D- and 2D-NMR spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated using three human cancer cell lines, HeLa, Caco2, and U87. Compound 3 exhibited significant cytotoxic activity against HeLa cells with an ICvalue of 11.18 μM. Additionally, the cytoprotective activity of these compounds was determined in vitro against HO-induced pancreatic injury. The results revealed that all the compounds obtained possess cytoprotective effects against HO-induced injury in MIN6β-cells at a concentration of 10 μM.

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