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Abstract Title:

Exposure to bisphenol A and breast cancer risk in northern Mexican women.

Abstract Source:

Int Arch Occup Environ Health. 2021 Jan 3. Epub 2021 Jan 3. PMID: 33392751

Abstract Author(s):

Lizbeth López-Carrillo, Ángel Mérida-Ortega, Humberto Gómez-Ruiz, Lucia Hernández-Garciadiego, Brenda Gamboa-Loira

Article Affiliation:

Lizbeth López-Carrillo

Abstract:

OBJECTIVE: To evaluate the association between BC and urinary concentrations of free-bisphenol A (BPA-F), the biological form of BPA, among women residing in Northern Mexico.

METHODS: The population under study comprised 394 histologically confirmed BC cases and 404 age-matched controls. Women were interviewed face to face about their sociodemographic and reproductive characteristics. BPA-F was determined by high-pressure liquid chromatography equipped with a fluorescence detector (HPLC/FLD). Logistic regression models were used to estimate the adjusted BC risk in relation to BPA-F.

RESULTS: BPA-F geometric mean was significantly higher among cases compared to controls (3.16 μg/L in cases and 2.47 μg/L in controls). A significant adjusted BC odds ratio of 2.31 (95% CI: 1.43-3.74) was estimated for the highest category of BPA-F compared to the lowest category.

CONCLUSION: BPA-F may be an environmental cofactor of BC. Since this is the first report on BPA-F association with BC, our results need to be replicated.

Study Type : Human Study

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