Fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats. - GreenMedInfo Summary
Fresh garlic amelioration of high-fat-diet induced fatty liver in albino rats.
J Pak Med Assoc. 2015 Oct ;65(10):1102-7. PMID: 26440842
OBJECTIVE: To observe the effect of fresh garlic on high-fat-diet-induced fatty liver changes.
METHODS: The experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from October to November 2008, and comprised adult albino rats weighing 200-240g each. The rats were divided into 5 groups according to dietary regimen for eight weeks each. Group A received control diet; Group B received high saturated fat diet; Group C received high unsaturated fat diet; Group D received high saturated fat diet with fresh garlic; and Group E received high unsaturated fat diet with garlic for 8 weeks. Liver tissue slides were stained with Oil red-O and haematoxylin and Periodic acid-Schiff-haematoxylin.
RESULTS: The 50 rats in the study were divided into five groups of 10(20%) each. There was marked deposition of fat in hepatocyte along with marked decrease in glycogen content in liver of rats in Groups B and C, with Group B showing more marked changes. The changes in fat and glycogen content were reversed and ameliorated close to Group A in rats belonging to Groups D and E.
CONCLUSIONS: Fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats.