Abstract Title:

Fructose-induced hyperuricemia in essential hypertension.

Abstract Source:

Metabolism. 1977 Nov;26(11):1219-23. PMID: 909398

Abstract Author(s):

E Fiaschi, B Baggio, S Favaro, A Antonello, E Camerin, S Todesco, A Borsatti

Abstract:

A rapid intravenous fructose load was given to nine normouricemic essential hypertensive and eight control subjects. The following increase in plasma uric acid concentration was significantly higher in hypertensives than in controls. There was no significant difference in urinary excretion of urate between the two groups. Since the increase in uric acid concentration brought about by fructose is most probably due to an increased metabolism of preformed purine nucleotides, it is suggested that essential hypertensive patients have a higher than normal "pool" of purine nucleotides.

Study Type : Human Study

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