Fructose is used to induce elevated triglycerides in the animal model. - GreenMedInfo Summary
Interaction of dietary carbohydrate and fat in the regulation of hepatic and extrahepatic lipogenesis in the rat.
Br J Nutr. 1988 Mar;59(2):233-41. PMID: 3358925
Biochemistry Department, Memorial University of Newfoundland, St John's, Canada.
1. In order to examine the interaction of dietary fat and carbohydrate in the regulation of lipid metabolism, we have studied hepatic and extrahepatic lipogenesis, and adipose tissue lipoprotein lipase (EC 184.108.40.206) in rats fed on one of the following diets: a fructose-based diet containing 0 (F0) or 150 g maize oil (F15)/kg, or a glucose-based diet containing 0 (G0) or 150 g maize oil (G15)/kg. 2. The rats were meal-fed on the diets for 2 weeks after which the activities of a number of hepatic 'lipogenic' enzymes were measured and the activity of epididymal-fat-pad lipoprotein lipase. The activities of the lipogenic enzymes were: F0 greater than G0 greater than G15 greater than F15. Lipoprotein lipase activity was F0 = G0 = F15 = G15. The percentage of total body fatty acid synthesis which occurred in the liver was F0 greater than G0 greater than F15 greater than G15. 3. We conclude that fructose-induced hypertriglyceridaemia is primarily a result of the increased hepatic synthesis rather than decreased adipose-tissue lipoprotein lipase activity.