Abstract Title:

Interaction of dietary carbohydrate and fat in the regulation of hepatic and extrahepatic lipogenesis in the rat.

Abstract Source:

Br J Nutr. 1988 Mar;59(2):233-41. PMID: 3358925

Abstract Author(s):

G R Herzberg, M Rogerson

Article Affiliation:

Biochemistry Department, Memorial University of Newfoundland, St John's, Canada.

Abstract:

1. In order to examine the interaction of dietary fat and carbohydrate in the regulation of lipid metabolism, we have studied hepatic and extrahepatic lipogenesis, and adipose tissue lipoprotein lipase (EC 3.1.1.34) in rats fed on one of the following diets: a fructose-based diet containing 0 (F0) or 150 g maize oil (F15)/kg, or a glucose-based diet containing 0 (G0) or 150 g maize oil (G15)/kg. 2. The rats were meal-fed on the diets for 2 weeks after which the activities of a number of hepatic 'lipogenic' enzymes were measured and the activity of epididymal-fat-pad lipoprotein lipase. The activities of the lipogenic enzymes were: F0 greater than G0 greater than G15 greater than F15. Lipoprotein lipase activity was F0 = G0 = F15 = G15. The percentage of total body fatty acid synthesis which occurred in the liver was F0 greater than G0 greater than F15 greater than G15. 3. We conclude that fructose-induced hypertriglyceridaemia is primarily a result of the increased hepatic synthesis rather than decreased adipose-tissue lipoprotein lipase activity.

Study Type : Animal Study
Additional Links
Problem Substances : Fructose : CK(361) : AC(106)
Adverse Pharmacological Actions : Dyslipidemic : CK(32) : AC(8)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.