Abstract Title:

[Inhibition of fructose-induced hyperuricacidemia by pretreatment with phosphates].

Abstract Source:

Boll Soc Ital Biol Sper. 1982 Apr 30;58(8):491-6. PMID: 7093059

Abstract Author(s):

G Morozzi, C Berti, R Pellegrini, M Lalumera, R Marcolongo

Abstract:

To test the hypothesis that intravenous injections of fructose rapidly decreases liver ATP and Pi and results in the rapid degradation of adenine nucleotides and hyperuricemia, fructose was administered intravenously to a group of normal and gouty subjects; 4 gouty patients were treated with a phosphate solution prior fructose loading. The results obtained show that fructose administration plus phosphate solution prevents Pi depletion and inhibits fructose-induced hyperuricemia.

Study Type : Human Study

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