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Article Publish Status: FREE
Abstract Title:

Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius.

Abstract Source:

Mycobiology. 2016 Jun ;44(2):117-20. Epub 2016 Jun 30. PMID: 27433123

Abstract Author(s):

Ji-Yul Kim, Dae-Won Kim, Byung Soon Hwang, E-Eum Woo, Yoon-Ju Lee, Kyeong-Woon Jeong, In-Kyoung Lee, Bong-Sik Yun

Article Affiliation:

Ji-Yul Kim

Abstract:

During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance ((1)H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1µM.

Study Type : In Vitro Study

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Sayer Ji
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