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Article Publish Status: FREE
Abstract Title:

Protective Effects of Fucoidan Isolated from Celluclast-Assisted Extract ofSporophylls against AAPH-Induced Oxidative Stress In Vitro and In Vivo Zebrafish Model.

Abstract Source:

Molecules. 2020 May 19 ;25(10). Epub 2020 May 19. PMID: 32438702

Abstract Author(s):

Jae-Young Oh, Eun-A Kim, Sang In Kang, Hye-Won Yang, Bomi Ryu, Lei Wang, Jung-Suck Lee, You-Jin Jeon

Article Affiliation:

Jae-Young Oh

Abstract:

Fucoidan is a fucose-enriched polysaccharide, obtained from brown algae, with demonstrated antioxidant properties. However, traditional extraction methods using water or chemical-based extraction methods have reduced yield and produced hazardous by-products. In this study, we isolated fucoidan at a high yield using enzyme-assisted extraction; the Celluclast enzyme assisted extract ofsporophylls (FCUS). To examine the antioxidant properties of FCUS, oxidative stress was induced with 2,2'-azobis (2-methylpropionamidine) dihydrochloride (AAPH) in Vero cells and zebrafish model. FCUS was composed of 30.4% sulfate and 52.3% fucose. Pre-treatment of Vero cells with FCUS dose dependently inhibited AAPH-induced reactive oxygen species (ROS) production. Moreover, FCUS remarkably reduced cell death, ROS generation, and lipid peroxidation production in zebrafish larvae. Overall, these findings indicate that the sulfate-rich fucoidan of FCUS, obtained with an eco-friendly process, could be implemented as a beneficial antioxidant agent in the functional food industry.

Study Type : Animal Study, In Vitro Study

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