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Abstract Title:

Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme,α-glucosidase.

Abstract Source:

Int J Biol Macromol. 2020 Feb 15. Epub 2020 Feb 15. PMID: 32070744

Abstract Author(s):

Chantal Désirée Daub, Blessing Mabate, Samkelo Malgas, Brett Ivan Pletschke

Article Affiliation:

Chantal Désirée Daub

Abstract:

Ecklonia maxima, an endemic South African seaweed, is a potential source of beneficial bioactive compounds. Among these compounds, fucoidan, a sulphated polysaccharide has a wide range of bioactivities including anti-diabetic activity. In this study, fucoidan was extracted from E. maxima by the hot water extraction method and then characterised by colorimetric assays for sugar composition. The extraction from E. maxima yielded 6.12% fucoidan which was found to contain 4.45 ± 0.25% L-fucose and 6.01 ± 0.53% sulphate. The water extracted E. maxima fucoidan had a low molecular weight of approximately 10-30 kDa. Structural studies (FT-IR, NMR and XRD) confirmed the structure and integrity of the fucoidan to be similar to previously studied fucoidans in literature. Finally, the activities of starch digestive enzymes; α-amylase and α-glucosidase, were investigated in the presence of the E. maxima fucoidan extract. Fucoidan from E. maxima was observed to be a potent mixed-type inhibitor of α-glucosidase with an ICrange of 0.27-0.31 mg/ml, which was significantly lower than the commercial anti-diabetic standard, acarbose. Our present study demonstrated that fucoidan from E. maxima is a more powerful inhibitor compared to some standard anti-diabetic compounds and thus shows great potential for managing type 2 diabetes.

Study Type : In Vitro Study

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