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Abstract Title:

In vitro and in silico inhibition properties of fucoidan againstα-amylase and α-D-glucosidase with relevance to type 2 diabetes mellitus.

Abstract Source:

Carbohydr Polym. 2019 Apr 1 ;209:350-355. Epub 2019 Jan 14. PMID: 30732817

Abstract Author(s):

Lakshmana Senthil S, Chandrasekaran Raghu, Arjun H A, Anantharaman P

Article Affiliation:

Lakshmana Senthil S

Abstract:

This study investigated the in vitro and in silico inhibitory properties of fucoidan extracted from Turbinaria conoides againstα-amylase and α-D-glucosidase. Extracted fucoidan contained 59 and 35% of fucose and sulphate and was characterized usingH NMR. Dose dependent inhibition assays showed maximum of 85 and 72% of inhibition forα-amylase and α-D-glucosidase at 2.07 and 1.03 μM concentration of fucoidan. The ICvalue of fucoidan was found to be 1.07 and 0.68 μM against α-amylase and α-D-glucosidase. In silico studies (grid based docking) by Schrödinger software revealed that fucoidan as a potent inhibitor for both α-amylase and α-D-glucosidase based on number of interactions, hydrogen bond length and binding energy. Furthermore, fucoidan fulfilled the pharmacokinetic properties thus promising to develop fucoidan as drug for type 2 DM.

Study Type : In Vitro Study

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Sayer Ji
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