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Abstract Title:

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment ofFucoidan against Metastatic Lung Cancer.

Abstract Source:

Int J Mol Sci. 2021 Aug 24 ;22(17). Epub 2021 Aug 24. PMID: 34502035

Abstract Author(s):

Wei Zhang, Juyoung Hwang, Dhananjay Yadav, Eun-Koung An, Minseok Kwak, Peter Chang-Whan Lee, Jun-O Jin

Article Affiliation:

Wei Zhang

Abstract:

Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.

Study Type : Animal Study

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Sayer Ji
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