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Article Publish Status: FREE
Abstract Title:

Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae.

Abstract Source:

Viruses. 2021 Mar 11 ;13(3). Epub 2021 Mar 11. PMID: 33799811

Abstract Author(s):

Malcolm Turk Hsern Tan, Yan Li, Mohamad Eshaghi Gorji, Zhiyuan Gong, Dan Li

Article Affiliation:

Malcolm Turk Hsern Tan

Abstract:

Human noroviruses (hNoVs) cause heavy disease burden worldwide and there is no clinically approved vaccination or antiviral hitherto. In this study, with the use of a zebrafish larva in vivo platform, we investigated the anti-hNoV potentials of fucoidan (from brown algae) and 2'-Fucosyllactose (2'-FL). As a result, although both fucoidan and 2'-FL were able to block hNoV GII.4 virus-like particle (VLPs) from binding to type A saliva as expected, only fucoidan, but not 2'-FL, was able to inhibit the replication of hNoV GII.P16-GII.4 in zebrafish larvae, indicating the possible needs of higher molecular weights for fucosylated carbohydrates to exert anti-hNoV effect.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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