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Article Publish Status: FREE
Abstract Title:

Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells.

Abstract Source:

Oncotarget. 2016 Jun 21 ;7(25):38025-38035. PMID: 27203545

Abstract Author(s):

Yazong Yang, Zixiang Gao, Yanhong Ma, Hongming Teng, Zundong Liu, Hengyun Wei, Yanbing Lu, Xiaofang Cheng, Lin Hou, Xiangyang Zou

Article Affiliation:

Yazong Yang

Abstract:

Lymphangiogenesis is one of the promoters of tumor lymphatic metastasis. Fucoidan which is a fucose-enriched sulfated polysaccharide has effect on various pharmacological activities including anti-metastasis activity. However, the inhibitory effect of fucoidan on lymphangiogenesis remains unclear. Here, fucoidan extracted from U. pinnatifida sporophylls suppressed HLECs proliferation, migration and tube-like structure formation, and had inhibitory effect of tumor-induced lymphangiogenesis in vitro. Additionally, we found that fucoidan had a dose-dependent depressive effect on the expressions of PROX1, vascular endothelial growth factor receptor 3 (VEGFR3), NF-κB, phospho-PI3K and phospho-Akt in HLECs. Moreover, anti-lymphangiogenesis effect of fucoidan was assessed by using mouse tumor model. In summary, fucoidan inhibit tumor lymphangiogenesis and lymphatic metastasis by suppressing the NF-κB/PI3K/Akt signaling pathway through reduced levels of PROX1and VEGFR3.

Study Type : In Vitro Study

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Sayer Ji
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