Fucoidan-Rich Substances fromImprove Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloidβ Production/Tau Hyperphosphorylation.
Mar Drugs. 2019 Oct 17 ;17(10). Epub 2019 Oct 17. PMID: 31627432
Seon Kyeong Park
() was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan = 4:6) on cognitive function. The ameliorating effect ofwas evaluated using the Y-maze, passive avoidance and Morris water maze tests with a trimethyltin (TMT)-induced cognitive dysfunction model, and the results showed that the fucoidan extract and mixture (4:6) had relatively higher learning and memory function effects than the polyphenol extract. After a behavioral test, the inhibitory effect of lipid peroxidation and cholinergic system activity were examined in mouse brain tissue, and the fucoidan extract and mixture (4:6) also showed greater improvements than the polyphenol extract. Mitochondrial activity was evaluated using mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP,ΔΨm), adenosine triphosphate (ATP) content, and mitochondria-mediated protein (BAX, cytochrome C) analysis, and these results were similar to the results of the behavioral tests. Finally, to confirm the cognitive function-related mechanism of, the amyloid-β production and tau hyperphosphorylation-medicated proteins were analyzed. Based on these results, the improvement effect ofwas more influenced by fucoidan than polyphenol. Therefore, our study suggests that the fucoidan-rich substances incould be a potential material for improving cognitive function by down-regulating amyloid-β production and tau hyperphosphorylation.