Abstract Title:

Fucoidan suppresses endocytosis in cultured HeLa cells.

Abstract Source:

Chin J Integr Med. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21853347

Abstract Author(s):

Hong Wu, Shui-Bo Gao, Takashi Sakurai, Susumu Terakawa

Article Affiliation:

The laboratory of Cell Imaging, Henan College of Traditional Chinese Medicine, Zhengzhou, 450002, China, kevin5me@yahoo.com.cn.


OBJECTIVE: To evaluate the effects of fucoidan on endocytosis in cultured HeLa cells: in vitro using live cell imaging. METHODS: A confocal scanning system and an incubation imaging system were used to: observe the effects of fucoidan on the initial (6 h) stages of endocytosis using the fl uorescent probe FM1-43 and inorganic fl uorescent quantum dot (Q-dots). RESULTS: According to the time-lapse images, fucoidan inhibited the: formation of endocytic vesicles in HeLa cells, in which the FM1-43 dye was entrapped. Fucoidan also had an inhibitory effect on the uptake of the Q-dots by the cell membranes of HeLa cells. CONCLUSION: It was concluded: that fucoidan suppresses Ca(2+)-dependent endocytosis in HeLa cells, which may be caused by its inhibitory -effects on agonist-induced Ca(2+) responses.

Study Type : In Vitro Study

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