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Abstract Title:

Fucoidans from brown algae Laminaria longipes and Saccharina cichorioides: Structural characteristics, anticancer and radiosensitizing activity in vitro.

Abstract Source:

Carbohydr Polym. 2019 Oct 1 ;221:157-165. Epub 2019 May 30. PMID: 31227154

Abstract Author(s):

Roza V Usoltseva, Natalia M Shevchenko, Olesya S Malyarenko, Stanislav D Anastyuk, Anna E Kasprik, Nikolay V Zvyagintsev, Svetlana P Ermakova

Article Affiliation:

Roza V Usoltseva

Abstract:

The sulfatedα-l-fucans ScF and LlF were obtained from brown algae of the Laminariaceae family (Saccharina cichorioides and Laminaria longipes). According to spectroscopy NMR, the LlF fucan predominantly contained the →3)-α-l-Fucp-(2SO-)-(1→4)-α-l-Fucp-(1→2)-α-l-Fucp-(4SO-)-(1→ repeating units, with small amounts of disaccharide 1,4-linked fragments and 3-sulfated fucose residues. Mass spectrometric analysis revealed the presence of the following fragments in the fucan structure: α-l-Fucp-(2SO-)-(1→4)-α-l-Fucp-(2SO-)-(1→3)-α-l-Fucp-(4SO-);α-l-Fucp-(2,4SO-)-(1→3)-α-l-Fucp-(1→3)-α-l-Fucp-(4SO-);α-l-Fucp-(2SO-)-(1→2)-α-l-Fucp; α-l-Fucp-(2SO-)-(1→2)-α-l-Fucp-(4SO-);α-l-Fucp-(2SO-)-(1→3)-α-l-Fucp; α-l-Fucp-(2,4SO-)-(1→3)-α-l-Fucp; α-l-Fucp-(4SO-)-(1→4)-α-l-Fucp; and α-l-Fucp-(4SO-)-(1→4)-α-l-Fucp-(2SO-). Both ScF and LlF fucoidans inhibited colony formation and growth of melanoma and colon cancer cells and sensitize-tested cancer cells to X-ray radiation to a comparable degree.

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