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Abstract Title:

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.

Abstract Source:

Bioorg Med Chem. 2020 Oct 1 ;28(19):115663. Epub 2020 Jul 28. PMID: 32912432

Abstract Author(s):

Liqun Wang, Hongyao Liu, Qiurong He, Cailing Gan, Yali Li, Qianyu Zhang, Yuqin Yao, Fang He, Tinghong Ye, Wenya Yin

Article Affiliation:

Liqun Wang

Abstract:

Pulmonary fibrosis (PF) is a disease that is characterized by abnormal epithelial-mesenchymal transition (EMT) and persistent inflammatory injury, with high mortality and poor prognosis, but the current therapies are accompanied by certain adverse side effects. In this study, we investigated the role of galangin (GA), an anti-inflammatory and anti-tumoral phytochemical extracted from galangal, in preventing and curing bleomycin (BLM)-induced pulmonary fibrosis and the underlying mechanism. Histopathological staining confirmed that GA dramatically moderated bleomycin-induced pulmonary fibrosis in mice. Compared with the vehicle treatment, GA treatment inhibited the expression of vimentin and increased the expression of E-cadherin. The expression ofα-Smooth muscle actin (α-SMA), which is a myofibroblast marker, was also suppressed. In addition, GA diminished the increase in the numbers of CD4CD69and CD8CD69T cells and dendritic cells induced by bleomycin, and reduced the residence of inflammatory cells in the lung tissues. Notably, GA inhibited the TGF-β1-induced EMT and fibroblast differentiation in vitro, which further confirmed the potential protective effect of GA on pulmonary fibrosis. Taken together, our results suggest that GA exerts a beneficial effect on bleomycin-induced pulmonary fibrosis by attenuating EMT and inflammatory damage andmay have prevent potential of pulmonary fibrosis.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Anti-Fibrotic : CK(46) : AC(29)

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