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Abstract Title:

Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

Abstract Source:

Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID: 18374481

Abstract Author(s):

Manlio Tolomeo, Stefania Grimaudo, Antonietta Di Cristina, Rosaria M Pipitone, Luisa Dusonchet, Maria Meli, Lucia Crosta, Nicola Gebbia, Francesco Paolo Invidiata, Lucina Titone, Daniele Simoni

Article Affiliation:

Centro Interdipartimentale di Ricerca in Oncologia Clinica, Università di Palermo, Palermo, Italy. mtolomeo@hotmail.com

Abstract:

Resistance to imatinib mesylate is an emergent problem in the treatment of Bcr-Abl expressing myelogenous leukemias and additional therapeutic strategies are required. We observed that galangin, a non-toxic, naturally occurring flavonoid was effective as anti-proliferative, and apoptotic agent in Bcr-Abl expressing K562 and KCL22 cells and in imatinib mesylate resistant K562-R and KCL22-R cells. Galangin induced an arrest of cells in G0-G1phase of cell cycle and a decrease in pRb, cdk4, cdk1, cycline B levels; moreover, it was able to induce a monocytic differentiation of leukemic Bcr-Abl+ cells. Of note, galangin caused a decrease in Bcl-2 levels and markedly increased the apoptotic activity of imatinib both in sensitive or imatinib-resistant Bcr-Abl+ cell lines. In contrast, flavonoids unable to modify the Bcl-2 intracellular levels, such as fisetin and chrysin, did not increase the apoptotic effect of imatinib. These data suggest that galangin is an interesting candidate for a combination therapy in the treatment of imatinib-resistant leukemias.

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