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Abstract Title:

Cytotoxicity ofδ-tocotrienols from Kielmeyera coriacea against cancer cell lines.

Abstract Source:

Bioorg Med Chem. 2011 Jan 1;19(1):623-30. Epub 2010 Oct 25. PMID: 21094611

Abstract Author(s):

Mariana Laundry de Mesquita, Renata Mendonça Araújo, Daniel Pereira Bezerra, Raimundo Braz Filho, José Elias de Paula, Edilberto Rocha Silveira, Cláudia Pessoa, Manoel Odorico de Moraes, Letícia Veras Costa Lotufo, Laila Salmen Espindola

Article Affiliation:

Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brazil.

Abstract:

In the search for new anti-cancer compounds, Brazilian Cerrado plant species have been investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture ofδ-tocotrienol (1) and its dimer (2). The structures of both compounds 1 and 2 were established based on detailed 1D and 2D NMR and EI-MS analyses. The cytotoxicity of the mixture was tested against four human tumor cell lines in the following cultures: MDA-MB-435 (melanoma), HCT-8 (colon), HL-60 (leukemia), and SF-295 (glioblastoma), and displayed IC(50) values ranging from 8.08 to 23.58μg/mL. Additional assays were performed in order to investigate the mechanism of action of the mixture (1+2) against the human leukemia cell line HL-60. The results suggested that the mixture suppressed leukemia growth and reduced cell survival, triggering both apoptosis and necrosis, depending on the concentration.

Study Type : In Vitro Study

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