Gamma tocotrienol exhibits anti-cancer and anti-leukemia activity. - GreenMedInfo Summary
Cytotoxicity ofδ-tocotrienols from Kielmeyera coriacea against cancer cell lines.
Bioorg Med Chem. 2011 Jan 1;19(1):623-30. Epub 2010 Oct 25. PMID: 21094611
Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brazil.
In the search for new anti-cancer compounds, Brazilian Cerrado plant species have been investigated. The hexane root bark extract of Kielmeyera coriacea lead to a mixture ofδ-tocotrienol (1) and its dimer (2). The structures of both compounds 1 and 2 were established based on detailed 1D and 2D NMR and EI-MS analyses. The cytotoxicity of the mixture was tested against four human tumor cell lines in the following cultures: MDA-MB-435 (melanoma), HCT-8 (colon), HL-60 (leukemia), and SF-295 (glioblastoma), and displayed IC(50) values ranging from 8.08 to 23.58μg/mL. Additional assays were performed in order to investigate the mechanism of action of the mixture (1+2) against the human leukemia cell line HL-60. The results suggested that the mixture suppressed leukemia growth and reduced cell survival, triggering both apoptosis and necrosis, depending on the concentration.