Ganoderma Lucidum from red mushroom attenuates formaldehyde-induced liver damage. - GreenMedInfo Summary
from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.
Biology (Basel). 2020 Sep 27 ;9(10). Epub 2020 Sep 27. PMID: 32992510
Babatunde Oluwafemi Adetuyi
The majority of liver-related illnesses are caused by occupational and domestic exposure to toxic chemicals like formaldehyde (FA), which is widely common in Africa and the world at large. Hence, measures should be taken to protect humans from its hazardous effects. This study, therefore, examines the protective potential of(100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation in male rats. Male Wistar rats, 150-200 g, were allotted into four groups of 10 animals as follows: Group 1 was orally treated with 1 mg/mL distilled water, Group 2 was exposed to a 40% formaldehyde vapor environment for 30 min per day, Group 3 was orally treated with 100 mg/kg ethanol extract of, and Group 4 was co-administered formaldehyde and 100 mg/kg ethanol extract of. Rats were then sacrificed 24 h after administering the last dose of treatment, and the livers were excised.significantly reversed the formaldehyde-mediated reduction in body and organ weight.administration significantly prevented oxido-inflammation by reducing the levels of hydrogen peroxide and malondialdehyde and increasing the activity of antioxidant enzymes and glutathione contents, as well as the normal level of nitrite and myeloperoxidase production in FA-treated rats. Additionally,reversed a large decline in proinflammatory markers in formaldehyde. Furthermore,restores formaldehyde-induced histological alterations in the liver. Collectively, our results provide valuable information on the protective potential ofin protecting formaldehyde-induced liver oxido-inflammation in male rats.