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Abstract Title:

Anti-HIV-1 protostane triterpenes and digeranylbenzophenone from trunk bark and stems of Garcinia speciosa.

Abstract Source:

Planta Med. 2003 Dec;69(12):1141-6. PMID: 14750032

Abstract Author(s):

Vatcharin Rukachaisirikul, Phanruethai Pailee, Assdhawut Hiranrat, Patoomratana Tuchinda, Chalobon Yoosook, Jittra Kasisit, Walter C Taylor, Vichai Reutrakul

Article Affiliation:

Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla,Thailand.

Abstract:

Three new protostanes, garciosaterpenes A ( 1), B ( 2) and C ( 3), together with a new digeranylbenzophenone, garciosaphenone A ( 4) were isolated from the ethyl acetate fractions obtained from the crude methanol extracts of the trunk bark and stems of Garcinia speciosa. The structures were elucidated by spectroscopic methods and chemical reactions. Compounds 1 and 3 showed significant inhibitory activities (IC (50) 15.5 and 12.2 microg/mL, respectively) against HIV-1 reverse transcriptase and in the syncytium assay (EC (50) 5.8 microg/mL with TI 3.4 and 37.0 microg/mL with TI 1.9, respectively). Compound 4 was active in HIV-1 RT assay (IC (50) 23.9 microg/mL), but toxic in the syncytium assay. This work represents the first report on the anti-HIV-1 activities of the protostane triterpenes.

Study Type : In Vitro Study

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