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Abstract Title:

A novel xanthone dimer derivative with antibacterial activity isolated from the bark of Garcinia mangostana.

Abstract Source:

Nat Prod Res. 2017 Nov 13:1-6. Epub 2017 Nov 13. PMID: 29132213

Abstract Author(s):

Weiyi Wang, Yanyan Liao, Xiaomei Huang, Chao Tang, Peng Cai

Article Affiliation:

Weiyi Wang

Abstract:

A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2-11), were isolated from bark of Garcinia mangostana. Their structures were established through spectroscopic methods. Garmoxanthone exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of both 3.9 μg/mL) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 31.2 μg/mL). Garmoxanthone is a unique xanthone dimer with linkage of a fused 5/6 ring system and its absolute configuration was elucidated on the basis of experimental and calculated electronic circular dichroism. Garmoxanthone exhibited strong antibacterial activity which partially validated the ethnobotanical use of G. mangostana in the treatment of infections.

Study Type : In Vitro Study

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